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1

Gene Therapy: Socioeconomic and Ethical Issues A Roundtable Discussion

Hillman, Alan L., Brenner, Malcolm K., Caplan, Arthur L., Carey, John, Champey, Yves, Culver, Kenneth W., Drummond, Michael F., Freund, Deborah A., Holmes, Edward W., Kelley, William N., Kolata, Gina,

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 540 KB

english, 1996

2

Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors

Porter, Caroline E., Rosewell Shaw, Amanda, Jung, Youngrock, Yip, Tiffany, Castro, Patricia D., Sandulache, Vlad C., Sikora, Andrew, Gottschalk, Stephen, Ittman, Michael M., Brenner, Malcolm K., Suzuk

Journal:

Molecular Therapy

Year:

2020

File:

PDF, 2.39 MB

2020

3

CAR T cell therapy for breast cancer: harnessing the tumor milieu to drive T cell activation

Bajgain, Pradip, Tawinwung, Supannikar, D’Elia, Lindsey, Sukumaran, Sujita, Watanabe, Norihiro, Hoyos, Valentina, Lulla, Premal, Brenner, Malcolm K., Leen, Ann M., Vera, Juan F.

Journal:

Journal for ImmunoTherapy of Cancer

Year:

2018

Language:

english

File:

PDF, 3.12 MB

english, 2018

4

Clinical Success of Complex Biological Therapies: Be Careful What You Wish For...

Brenner, Malcolm K

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 182 KB

english, 2010

5

Cancer Gene Therapy by Viral and Non-viral Vectors (Brenner/Cancer Gene Therapy by Viral and Non-viral Vectors) || Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core Nanoparticles

Brenner, Malcolm K., Hung, Mien-Chie

Year:

2014

Language:

english

File:

PDF, 451 KB

english, 2014

6

Adoptive Cell Therapy for Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia

Lulla, Premal D., Mamonkin, Maksim, Brenner, Malcolm K.

Journal:

The Cancer Journal

Year:

2019

Language:

english

File:

PDF, 263 KB

english, 2019

7

Cord Blood Transplant for Very High Risk Hematologic Malignancies in Children Using Conditioning Without Serotherapy

Onishi, Toshihiro, John, Tami, Aguayo-Hiraldo, Paibel Ixia, Tewari, Priti, Naik, Swati, Omer, Bilal, Hegde, Meena, Ahmed, Nabil, Sasa, Ghadir, Brenner, Malcolm K., Heslop, Helen E., Krance, Robert A.,

Journal:

Biology of Blood and Marrow Transplantation

Year:

2018

Language:

english

File:

PDF, 111 KB

english, 2018

8

Lymphokines and interferons: A practical approach: Clemens, M.J., Morris, A.G. and Gearing, A.J.H., v + 376 pp. IRL Press, Oxford, 1987. £22.00, ISBN 1-85221-035-4

Malcolm Brenner

Journal:

Journal of Immunological Methods

Year:

1988

Language:

english

File:

PDF, 70 KB

english, 1988

9

Seek and You Will Not Find: Ending the Hunt for Replication-Competent Retroviruses during Human Gene Therapy

Heslop, Helen E., Brenner, Malcolm K.

Journal:

Molecular Therapy

Year:

2018

Language:

english

File:

PDF, 195 KB

english, 2018

10

Defining the risks of mesenchymal stromal cell therapy

Prockop, Darwin J., Brenner, Malcolm, Fibbe, Willem E., Horwitz, Edwin, Le Blanc, Katarina, Phinney, Donald G., Simmons, Paul J., Sensebe, Luc, Keating, Armand

Journal:

Year:

2010

Language:

english

File:

PDF, 160 KB

english, 2010

11

10.1038/83276

Horwitz, Edwin M., Prockop, Darwin J., Fitzpatrick, Lorraine A., Koo, Winston W.K., Marx, Jeffrey C., Brenner, Malcolm K.

Journal:

Nature Medicine

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

12

Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Donald R. Shaffer, Andrea M. Sheehan, Zhongzhen Yi, Cheryl C. Rodgers, Catherine M. Bollard, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, Stephen Gottschalk

Journal:

Pediatric Blood & Cancer

Year:

2012

Language:

english

File:

PDF, 299 KB

english, 2012

13

Autologous Bone Marrow Transplant for Children with AML in First Complete Remission: Use of Marker Genes to Investigate the Biology of Marrow Reconstitution and the Mechanism of Relapse

Brenner, Malcolm, Mirro, Joseph, Hurwitz, Craig, Santana, Victor, Ihle, James, Krance, Robert, Ribeiro, Raul, Roberts, W. Mark, Mahmoud, Hazem, Schell, Michael, Garth, Katy, Moen, Robert C., French-An

Journal:

Human Gene Therapy

Year:

1991

Language:

english

File:

PDF, 3.53 MB

english, 1991

14

The Continuing Contribution of Gene Marking to Cell and Gene Therapy

Tey, Siok-Keen, Brenner, Malcolm K

Journal:

Molecular Therapy

Year:

2007

Language:

english

File:

PDF, 413 KB

english, 2007

15

3D modeling of human cancer: a PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus

Del Bufalo, Francesca, Manzo, Teresa, Hoyos, Valentina, Yagyu, Shigeki, Caruana, Ignazio, Jacot, Jeffrey, Benavides, Omar, Rosen, Daniel, Brenner, Malcolm K.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

16

513. Armed-Ad Gene Therapy Expressing PD-L1 Minibody Enhances the Anti-Tumor Effect of Adoptively Transferred Chimeric Antigen Receptor T-Cells for Solid Tumor Treatment

Shaw, Amanda Rosewell, Tanoue, Kiyonori, Watanabe, Norihiro, Porter, Caroline, Brenner, Malcolm, Suzuki, Masataka

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 648 KB

english, 2016

17

411. CD5 CAR for the Treatment of T-Cell Malignancies

Mamonkin, Maksim, Brenner, Malcolm K.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 314 KB

english, 2015

18

Umbilical Cord Transplant (UCBT) Without Serotherapy for Malignant and Non Malignant Diseases Provides a Curative Alternative with Improved Immune Reconstitution

Aguayo-Hiraldo, Paibel Ixia, Forbes, Lisa, Shearer, William, Orange, Jordan, Naik, Swati, Sasa, Ghadir, Leung, Kathryn, Gottschalk, Stephen, Allen, Carl, Ahmed, Nabil, Brenner, Malcolm K., Leen, Ann M

Journal:

Biology of Blood and Marrow Transplantation

Year:

2017

Language:

english

File:

PDF, 98 KB

english, 2017

19

Multiple mechanisms determine the sensitivity of human-induced pluripotent stem cells to the inducible caspase-9 safety switch

Yagyu, Shigeki, Hoyos, Valentina, Del Bufalo, Francesca, Brenner, Malcolm K.

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2016

Language:

english

File:

PDF, 1.07 MB

english, 2016

20

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

Gomes-Silva, Diogo, Mukherjee, Malini, Srinivasan, Madhuwanti, Krenciute, Giedre, Dakhova, Olga, Zheng, Yueting, Cabral, Joaquim M.S., Rooney, Cliona M., Orange, Jordan S., Brenner, Malcolm K., Mamonk

Journal:

Year:

2017

Language:

english

File:

PDF, 2.76 MB

english, 2017

21

Optimizing C-Type Lectin-like Molecule 1 (CLL-1) Directed CAR T Cell Therapy of Acute Myeloid Leukemia

Atilla, Pinar Ataca, Atilla, Erden, Tashiro, Haruko, Srinivasan, Madhuwanti, Silva, Diogo Gomes, Mamonkin, Maksim, Brenner, Malcolm K.

Journal:

Biology of Blood and Marrow Transplantation

Year:

2019

Language:

english

File:

PDF, 482 KB

english, 2019

22

T cell receptors and cancer: gain gives pain

Brenner, Malcolm

Journal:

Nature Medicine

Year:

2010

Language:

english

File:

PDF, 458 KB

english, 2010

23

Cancer Gene Therapy: What it Can and Cannot Do

Brenner, Malcolm K.

Journal:

Journal of Vascular and Interventional Radiology

Year:

2000

Language:

english

File:

PDF, 810 KB

english, 2000

24

CANCER VACCINES

Rousseau, Raphaël F., Hirschmann-Jax, Charlotte, Takahashi, Satoshi, Brenner, Malcolm K.

Journal:

Hematology/Oncology Clinics of North America

Year:

2001

Language:

english

File:

PDF, 1.78 MB

english, 2001

25

Gene-Modified Cells for Stem Cell Transplantation and Cancer Therapy

Brenner, Malcolm K.

Journal:

Human Gene Therapy

Year:

2014

Language:

english

File:

PDF, 154 KB

english, 2014

26

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

Dotti, Gianpietro, Savoldo, Barbara, Brenner, Malcolm

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 11.51 MB

english, 2009

27

Gene Marking to Improve the Outcome of Autologous Bone Marrow Transplantation

BRENNER, MALCOLM K., RILL, DONNA R.

Journal:

Journal of Hematotherapy

Year:

1994

Language:

english

File:

PDF, 524 KB

english, 1994

28

Cancer Gene Therapy by Viral and Non-viral Vectors (Brenner/Cancer Gene Therapy by Viral and Non-viral Vectors) || Retroviruses for Cancer Therapy

Brenner, Malcolm K., Hung, Mien-Chie

Year:

2014

Language:

english

File:

PDF, 373 KB

english, 2014

29

SPIE Proceedings [SPIE SPIE LASE - San Francisco, California, United States (Saturday 1 February 2014)] Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XIV - Plasmonic nanobubbles for target cell-specific gene and drug delivery and multifunctional processing of heterogeneous cell systems

Heisterkamp, Alexander, Herman, Peter R., Meunier, Michel, Nolte, Stefan, Lukianova-Hleb, Ekaterina Y., Huye, Leslie E., Brenner, Malcolm K., Lapotko, Dmitri O.

Year:

2014

Language:

english

File:

PDF, 425 KB

english, 2014

30

Delayed Induction of Proto-Oncogene Expression in B-CLL Cells by Tumor Necrosis Factor

Gignac, Suzanne M., Buschle, Michael, Heslop, Helen E., Brenner, Malcolm K., Hoffbrand, A. Victor, Drexler, Hans G.

Journal:

Leukemia and Lymphoma

Year:

1990

Language:

english

File:

PDF, 1.29 MB

english, 1990

31

Phase I Trial of Vaccination With Autologous Neuroblastoma Tumor Cells Genetically Modified to Secrete IL-2 and Lymphotactin

Russell, Heidi V., Strother, Douglas, Mei, Zhuyong, Rill, Donna, Popek, Edwina, Biagi, Ettore, Yvon, Eric, Brenner, Malcolm, Rousseau, Raphael

Journal:

Journal of Immunotherapy

Year:

2007

Language:

english

File:

PDF, 121 KB

english, 2007

32

210. High Expression of Second Generation CD19 CAR with a 4-1BB Costimulatory Domain from a Retroviral Vector Impairs CAR T Cell Expansion by Enhancing Fas-Mediated Apoptosis

Silva, Diogo, Mukherjee, Malini, Srinivasan, Madhuwanti, Orange, Jordan S., Brenner, Malcolm K., Mamonkin, Maksim

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

33

The best cytokine for the job

Dilloo, Dagmar, Brenner, Malcolm

Journal:

Nature Medicine

Year:

1997

File:

PDF, 133 KB

1997

34

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells: A model for immunotherapy

Gianpietro Dotti, Barbara Savoldo, Satoshi Takahashi, Tatiana Goltsova, Michael Brown, Donna Rill, Cliona Rooney, Malcolm Brenner

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

35

High-Efficiency Transduction of Freshly Isolated Human Tumor Cells Using Adenoviral Interleukin-2 Vectors

Leimig, Thasia, Brenner, Malcolm, Ramsey, Jay, Vanin, Elio, Blaese, Michael, Dilloo, Dagmar

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 5.42 MB

english, 1996

36

Reversal of Tumor Immune Inhibition Using a Chimeric Cytokine Receptor

Leen, Ann M., Sukumaran, Sujita, Watanabe, Norihiro, Mohammed, Somala, Keirnan, Jacqueline, Yanagisawa, Ryu, Anurathapan, Usanarat, Rendon, David, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm

Journal:

Molecular Therapy

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

37

Cancer Gene Therapy by Viral and Non-viral Vectors (Brenner/Cancer Gene Therapy by Viral and Non-viral Vectors) || DNA Plasmids for Non-viral Gene Therapy of Cancer

Brenner, Malcolm K., Hung, Mien-Chie

Year:

2014

Language:

english

File:

PDF, 380 KB

english, 2014

38

Generation of Human Dendritic Cells That Simultaneously Secrete IL-12 and Have Migratory Capacity by Adenoviral Gene Transfer of hCD40L in Combination With IFN-γ

Knippertz, Ilka, Hesse, Andrea, Schunder, Tanja, Kämpgen, Eckhart, Brenner, Malcolm K., Schuler, Gerold, Steinkasserer, Alexander, Nettelbeck, Dirk M.

Journal:

Journal of Immunotherapy

Year:

2009

Language:

english

File:

PDF, 497 KB

english, 2009

39

762. A Quantitative Imaging Tool Box for the Functional Analysis of Chimeric Antigen Receptor - T Cell Immune Synapse Helps Identify Novel Structural and Functional Features of CAR T Cells

Mukherjee, Malini, Mamonkin, Maksim, Ahmed, Nabil, Brenner, Malcolm, Orange, Jordan

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 333 KB

english, 2016

40

Allogeneic hematopoietic stem cell transplant for relapsed and refractory non-Hodgkin lymphoma in pediatric patients

Naik, Swati, Martinez, Caridad A., Omer, Bilal, Sasa, Ghadir, Yassine, Khaled, Allen, Carl E., Kamdar, Kala, Orth, Robert, Wu, Mengfen, Leung, Kathryn, Gottschalk, Stephen, Brenner, Malcolm K., Heslop

Journal:

Year:

2019

File:

PDF, 954 KB

2019

41

Adenoviral gene transfer into dendritic cells efficiently amplifies the immune response to LMP2A antigen: A potential treatment strategy for Epstein-Barr virus–positive Hodgkin's lymphoma

Benedikt Gahn, Fernando Siller-Lopez, Angela D. Pirooz, Eric Yvon, Stephen Gottschalk, Richard Longnecker, Malcolm K. Brenner, Helen E. Heslop, Estuardo Aguilar-Cordova, Cliona M. Rooney

Journal:

International Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 156 KB

english, 2001

42

Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy

Robert A. Krance, Ingrid Kuehnle, Donna R. Rill, Zhuyong Mei, Carl Pinetta, William Evans, Michael P. Brown, Martin Pulé, Helen E. Heslop, Malcolm K. Brenner

Journal:

Biology of Blood and Marrow Transplantation

Year:

2003

Language:

english

File:

PDF, 1.44 MB

english, 2003

43

790 SYSTEMIC T-CELL ACTIVATION FOLLOWING NEOADJUVANT IN SITU GENE THERAPY IN HIGH-RISK PROSTATE CANCER PATIENTS

Satoh, Takefumi, Kubo, Makoto, Tabata, Ken-ichi, Kurosaka, Shinji, Matsumoto, Kazumasa, Fujita, Tetsuo, Obata, Fumiya, Nasu, Yasutomo, Kumon, Hiromi, Kadmon, Dov, Brenner, Malcolm K., Thompson, Timoth

Journal:

The Journal of Urology

Year:

2012

Language:

english

File:

PDF, 133 KB

english, 2012

44

Outcomes in Pediatric Patients With Engraftment Failure After Allogeneic Transplants

Naik, Swati, Martinez, Caridad, Bollard, Catherine M., El-Bietar, Javier Amin, Gottschalk, Stephen, Leung, Kathryn, Ahmed, Nabil M., Allen, Carl, Heslop, Helen E., Brenner, Malcolm K., Krance, Robert

Journal:

Biology of Blood and Marrow Transplantation

Year:

2013

Language:

english

File:

PDF, 74 KB

english, 2013

45

Gene Marking

Brenner, Malcolm

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 986 KB

english, 1996

46

Use of Double Marking with Retroviral Vectors to Determine Rate of Reconstitution of Untreated and Cytokine Expanded CD34 + Selected Marrow Cells in Patients Undergoing Autologous Bone Marrow Transplantation. St. Jude Children's Research Hospital, Memphis, Tennessee

Heslop, Helen E., Brenner, Malcolm K., Krance, Robert A., Bowman, Laura, Cunningham, John M., Richardson, Stacye, Alexander, Barbara, Heideman, Richard, Boyett, James M., Srivastava, Deo-Kumar, Marcus

Journal:

Human Gene Therapy

Year:

1996

Language:

english

File:

PDF, 891 KB

english, 1996

47

Gene Transfer in Haematological Malignancy

Brenner, Malcolm K.

Journal:

Annals of Medicine

Year:

1996

Language:

english

File:

PDF, 722 KB

english, 1996

48

Gene Transfer and the Treatment of Childhood Cancer

Brenner, Malcolm K.

Journal:

Cancer Investigation

Year:

1998

Language:

english

File:

PDF, 1.07 MB

english, 1998

49

Chimeric T-Cells for Therapy of CD30+ Hodgkin and Non-Hodgkin Lymphomas (HL & NHL)

Ramos, Carlos A., Ballard, Brandon, Liu, Enli, Dakhova, Olga, Mei, Zhuyong, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Gee, Adrian P., Chang, Bill H., Bollard, Catherine M., Brenner, Malcolm K., Dot

Journal:

Biology of Blood and Marrow Transplantation

Year:

2016

Language:

english

File:

PDF, 72 KB

english, 2016

50

An Optimized Process of Generating CAR-T Cells for Clinical Applications

Bajgain, Pradip, Mucharla, Roopa, Wilson, John, Lapteva, Natalia, Heslop, Helen E., Rooney, Cliona M., Brenner, Malcolm K., Leen, Ann M., Vera, Juan F.

Journal:

Biology of Blood and Marrow Transplantation

Year:

2016

Language:

english

File:

PDF, 47 KB

english, 2016

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